Article
A second-stage genome scan for QTLs influencing BMD variation.
Calcified tissue international - 1 Aug 2004
Huang Q-Y, Xu F-H, Shen H, Zhao L-J, Deng H-Y, Liu Y-J, Dvomyk V, Conway T, Davies K M, Li J-L, Liu Y-Z, Recker R R, Deng H-W
Abstract excerpt
Low bone mineral density (BMD) is a major risk factor for osteoporotic fracture. To identify genomic regions harboring quantitative trait loci (QTLs) contributing to BMD variation, we performed a two-stage genome screen. The first stage involved genotyping of a sample of 53 pedigrees with 630 individuals using 400 microsatellite markers spaced at approximately 10-cM intervals throughout the genome. Ten genomic...
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