Article
Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus.
Bone - 1 Jul 2000
Takacs I, Koller D L, Peacock M, Christian J C, Evans W E, Hui S L, Conneally P M, Johnston C C, Foroud T, Econs M J
Abstract excerpt
A major determinant of the risk for osteoporosis in later life is bone mineral density (BMD) attained during early adulthood. Bone mineral density is a complex trait that, presumably, is influenced by multiple genes. Interleukin-6 (IL-6) is an attractive candidate gene for osteoporosis susceptibility, because it has effects on bone cells and has been implicated in the pathogenesis of osteoporosis. Furthermore,...
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