Article
Loci for regulation of bone mineral density in men and women identified by genome wide linkage scan: the FAMOS study.
Human molecular genetics - 1 Apr 2005
Ralston Stuart H, Galwey Nick, MacKay Ian, Albagha Omar M E, Cardon Lon, Compston Juliet E, Cooper Cyrus, Duncan Emma, Keen Richard, Langdahl Bente, McLellan Alastair, O'Riordan Jeffrey, Pols Huibert A, Reid David M, Uitterlinden Andre G, Wass John, Bennett Simon T
Abstract excerpt
Osteoporosis is a common disease with a strong genetic component, characterized by reduced bone mass and an increased risk of fracture. Bone mineral density (BMD) is a highly heritable trait and a key determinant of osteoporotic fracture risk, but the genes responsible are incompletely defined. Here, we identified quantitative trait loci (QTL) for regulation of BMD by a genome wide scan involving 3691 individuals...
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