Article
Identification of a linkage disequilibrium block in chromosome 1q associated with BMD in premenopausal white women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2008
Ichikawa Shoji, Koller Daniel L, Curry Leah R, Lai Dongbing, Xuei Xiaoling, Pugh Elizabeth W, Tsai Ya-Yu, Doheny Kimberly F, Edenberg Howard J, Hui Siu L, Foroud Tatiana, Peacock Munro, Econs Michael J
Abstract excerpt
Osteoporosis is a complex disease with both genetic and environmental risk factors. A major determinant of osteoporotic fractures is peak BMD obtained during young adulthood. We previously reported linkage of chromosome 1q (LOD = 4.3) with variation in spinal areal BMD in healthy premenopausal white women. In this study, we used a two-stage genotyping approach to identify genes in the linked region that...
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