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Article

A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.

The Journal of biological chemistry - 14 Jun 2002

Yart Armelle, Roche Serge, Wetzker Reinhard, Laffargue Muriel, Tonks Nicholas, Mayeux Patrick, Chap Hugues, Raynal Patrick

Abstract excerpt

Although Gbetagamma is thought to mediate mitogen-activated protein kinase (MAPK) activation in response to G protein-coupled receptor stimulation, the mechanisms involved in this pathway have not been clearly defined. Phosphoinositide 3-kinase (PI3K) has been proposed as an early intermediate in this process, but its role has remained elusive. We have observed that dominant negative mutants of p110beta, but not...

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PMID: 11916960
DOI: 10.1074/jbc.M110411200

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LPA
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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