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Article

B cell receptor signaling: picky about PI3Ks.

Science signaling - 10 Aug 2010

Limon Jose J, Fruman David A

Abstract excerpt

The B cell receptor (BCR) and the pre-BCR control cell fate at many stages of B cell development, survival, and antigen response. Most of these processes require the activation of phosphatidylinositol 3-kinase (PI3K). Previous work has pointed to p110delta as the key catalytic isoform of PI3K for many B cell responses. A study of mice with different combinations of PI3K mutations confirms the central role of...

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Source

Identifiers

PMID: 20699473
DOI: 10.1126/scisignal.3134pe25

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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