Article
Functional independence and interdependence of the Src homology domains of phospholipase C-gamma1 in B-cell receptor signal transduction.
Molecular and cellular biology - 1 Nov 1999
DeBell K E, Stoica B A, Verí M C, Di Baldassarre A, Miscia S, Graham L J, Rellahan B L, Ishiai M, Kurosaki T, Bonvini E
Abstract excerpt
B-cell receptor (BCR)-induced activation of phospholipase C-gamma1 (PLCgamma1) and PLCgamma2 is crucial for B-cell function. While several signaling molecules have been implicated in PLCgamma activation, the mechanism coupling PLCgamma to the BCR remains undefined. The role of PLCgamma1 SH2 and SH3 domains at different steps of BCR-induced PLCgamma1 activation was examined by reconstitution in a PLCgamma-negative...
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