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Article

The pleckstrin homology domain of Gab-2 is required for optimal interleukin-3 signalsome-mediated responses.

Cellular signalling - 1 Aug 2006

Edmead Christine E, Fox Bridget C, Stace Catherine, Ktistakis Nicholas, Welham Melanie J

Abstract excerpt

The adaptor protein Gab-2 coordinates the assembly of the IL-3 signalsome comprising Gab-2, Grb2, Shc, SHP-2 and PI3K. To investigate the role of the pleckstrin homology domain of Gab-2 in this process, epitope-tagged wild type Gab-2 (WTGab-2), Gab-2 lacking its PH domain (DeltaPHGab-2) and the Gab-2 PH domain alone (PHGab-2) were inducibly expressed in IL-3-dependent BaF/3 cells. Expression of DeltaPHGab-2...

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Identifiers

PMID: 16275030
DOI: 10.1016/j.cellsig.2005.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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