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Article

Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation.

Proceedings of the National Academy of Sciences of the United States of America - 23 Nov 2004

Aiba Yuichi, Oh-hora Masatsugu, Kiyonaka Shigeki, Kimura Yayoi, Hijikata Atsushi, Mori Yasuo, Kurosaki Tomohiro

Abstract excerpt

The Ras signaling pathway plays a critical role in B lymphocyte development and activation, but its activation mechanism has not been well understood. At least one mode of Ras regulation in B cells involves a Ras-guanyl nucleotide exchange factor, RasGRP3. We demonstrate here that RasGRP3 undergo...

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Identifiers

PMID: 15545601
DOI: 10.1073/pnas.0407468101
PMCID: PMC528733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15545601-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation.PMID 15545601Read ↗

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