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Article

A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.

Nature cell biology - 1 Apr 2003

Plattner Rina, Irvin Brenda J, Guo Shuling, Blackburn Kevin, Kazlauskas Andrius, Abraham Robert T, York John D, Pendergast Ann Marie

Abstract excerpt

The c-Abl tyrosine (Tyr) kinase is activated after platelet-derived-growth factor receptor (PDGFR) stimulation in a manner that is partially dependent on Src kinase activity. However, the activity of Src kinases alone is not sufficient for activation of c-Abl by PDGFR. Here we show that functional phospholipase C-gamma1 (PLC-gamma1) is required for c-Abl activation by PDGFR. Decreasing cellular levels of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12652307
DOI: 10.1038/ncb949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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