Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation.

The Journal of biological chemistry - 18 Feb 2005

Montagner Alexandra, Yart Armelle, Dance Marie, Perret Bertrand, Salles Jean-Pierre, Raynal Patrick

Abstract excerpt

SHP2 was recently found to down-regulate PI3K activation by dephosphorylating Gab1 but the mechanisms explaining the positive role of the Gab1/SHP2 pathway in EGF-induced Ras activation remain ill defined. Substrate trapping experiments now suggest that SHP2 dephosphorylates other Gab1 phosphotyrosines located within a central region displaying four YXXP motifs. Because these sites are potential docking motifs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Protein Tyrosine Phosphatases

Share to ras GTPase-Activating Proteins

Share to ras Proteins

Share to Vero Cells

Source

Identifiers

PMID: 15574420
DOI: 10.1074/jbc.M410012200

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation.PMID 15574420Read ↗

Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor.Semantic proximity Read ↗

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.Semantic proximity Read ↗

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.Semantic proximity Read ↗

The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation.Semantic proximity Read ↗

Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor.Semantic proximity Read ↗

Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility.Semantic proximity Read ↗

Development of an efficient "substrate-trapping" mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gab1, and three other proteins as target substrates.Semantic proximity Read ↗

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.Semantic proximity Read ↗

Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1Semantic proximity Read ↗

Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.Semantic proximity Read ↗

Distinct requirements for Gab1 in Met and EGF receptor signaling <i>in vivo</i>Semantic proximity Read ↗

MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.