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G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction.

Molecular biology of the cell - 1 Oct 2008

García-Regalado Alejandro, Guzmán-Hernández María Luisa, Ramírez-Rangel Iliana, Robles-Molina Evelyn, Balla Tamas, Vázquez-Prado José, Reyes-Cruz Guadalupe

Abstract excerpt

G-protein coupled receptors activate heterotrimeric G proteins at the plasma membrane in which most of their effectors are intrinsically located or transiently associated as the external signal is being transduced. This paradigm has been extended to the intracellular compartments by studies in yeast showing that trafficking of Galpha activates phosphatidylinositol 3-kinase (PI3K) at endosomal compartments,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18701709
DOI: 10.1091/mbc.e07-10-1089
PMCID: PMC2555931

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LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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