Article
Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.
Molecular and cellular biology - 1 Jun 2002
Zhang Si Qing, Tsiaras William G, Araki Toshiyuki, Wen Gengyun, Minichiello Liliana, Klein Ruediger, Neel Benjamin G
Abstract excerpt
Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved. One potential mechanism for RTK specificity is control of the magnitude and kinetics of activation of downstream pathways. We have found that the protein tyrosine phosphatase Shp2 regulates the strength and duration of phosphatidylinositol...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Binding Sites
- Cell Membrane
- Cells, Cultured
- Enzyme Activation
- Epidermal Growth Factor
- Insulin-Like Growth Factor I
- Intracellular Signaling Peptides and Proteins
- Mice
- Mutation
- Phosphatidylinositol 3-Kinases