Article
Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction.
Mutagenesis - 1 Sept 2011
Wang Yiying, Meng Fanxue, Arlt Volker M, Mei Nan, Chen Tao, Parsons Barbara L
Abstract excerpt
Aristolochic acid (AA) is a strong cytotoxic nephrotoxin and carcinogen associated with the development of urothelial cancer in humans. AA induces forestomach, kidney and urothelial tract tumours in rats and mice. This study was conducted to characterise AA's carcinogenic mechanism of action and compare allele-specific competitive blocker-polymerase chain reaction (ACB-PCR)-based early detection of carcinogenic...
Topics
- Alleles
- Animals
- Aristolochic Acids
- Cell Transformation, Neoplastic
- Codon
- DNA Adducts
- Genes, ras
- Male
- Mutation
- Polymerase Chain Reaction
- Rats
- Rats, Transgenic