Article
Mutation spectrum of o-aminoazotoluene in the cII gene of lambda/lacZ transgenic mice (MutaMouse).
Mutation research - 5 Apr 2001
Kohara A, Suzuki T, Honma M, Hirano N, Ohsawa K, Ohwada T, Hayashi M
Abstract excerpt
The o-aminoazotoluene (AAT) has been evaluated as a possible human carcinogen by the International Agency for Research on Cancer. In rodents, it is carcinogenic mainly in the liver, and also in lung following long term administration. We previously examined in lambda/lacZ transgenic mice for the induction of lacZ mutations in liver, lung, urinary bladder, colon, kidney, bone marrow, and testis. AAT induced gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.