Article
Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2).
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Feb 2002
Lueders Kira K, Hu Stella, McHugh Louise, Myakishev Max V, Sirota Leo A, Hamer Dean H
Abstract excerpt
The beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2) is a logical candidate for influencing smoking behavior and nicotine dependence. We discovered six single nucleotide polymorphisms (SNPs) in the CHRNB2 gene by surveying 15.4 kb of genomic sequence including a previously undescribed 3' untranslated region that extends 4.0 kb downstream of the coding region. One of the SNPs causes an amino acid...
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