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Article

p53 Gene mutation and genetic instability in superficial multifocal esophageal squamous cell carcinoma.

International journal of oncology - 1 Apr 2002

Fujiki Takehiro, Haraoka Seiji, Yoshioka Shingo, Ohshima Koichi, Iwashita Akinori, Kikuchi Masahiro

Abstract excerpt

Tumor multicentricity is occasionally observed in esophageal squamous cell carcinoma (SCC). We studied five surgically resected superficial multifocal esophageal SCCs for p53 gene mutation and genetic instability, using DNA extracted from microdissected areas. A total of 38 target areas (TAs) were analyzed in SCC, dysplasia, basal cell hyperplasia (BCH) and normal squamous epithelium. Analysis of the replication...

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Source

Identifiers

PMID: 11894109

Genes

CAT
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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