Article
Clonal origin of multifocal hepatocellular carcinoma.
Cancer - 1 Sept 2010
Hodges Kurt B, Cummings Oscar W, Saxena Romil, Wang Mingsheng, Zhang Shaobo, Lopez-Beltran Antonio, Montironi Rodolfo, Nour Hammam, Cheng Liang
Abstract excerpt
BACKGROUND: Hepatocellular carcinoma is the most common primary tumor of the liver. Patients frequently have multiple histologically similar, but anatomically separate tumors. The clonal origin of multiple hepatocellular carcinomas is uncertain. METHODS: The authors analyzed 31 tumors from 12 different patients (11 women, 1 man), who had multiple hepatocellular carcinomas involving 1 or both lobes. Genomic DNA...
Topics
- Adult
- Aged
- Carcinoma, Hepatocellular
- Female
- Genes, p53
- Humans
- Liver Neoplasms
- Loss of Heterozygosity
- Male
- Middle Aged
- Mutation
- X Chromosome Inactivation