Article
Microsatellite alterations and target gene mutations in the early stages of multiple gastric cancer.
The Journal of pathology - 1 Jul 2001
Ogata S, Tamura G, Endoh Y, Sakata K, Ohmura K, Motoyama T
Abstract excerpt
Multiple gastric cancers may develop through the same genetic background: the mutator pathway due to defects in DNA mismatch repair genes, or the suppressor pathway due to defects in tumour suppressor genes. To clarify the critical genetic events in the early stages of multiple gastric cancer development, 29 early and four advanced gastric cancers were examined from 12 patients. Microsatellite alterations were...
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