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Article

Embryonic stem cells and somatic cells differ in mutation frequency and type.

Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002

Cervantes Rachel B, Stringer James R, Shao Changshun, Tischfield Jay A, Stambrook Peter J

Abstract excerpt

Pluripotent embryonic stem (ES) cells have been used to produce genetically modified mice as experimental models of human genetic diseases. Increasingly, human ES cells are being considered for their potential in the treatment of injury and disease. Here we have shown that mutation in murine ES cells, heterozygous at the selectable Aprt locus, differs from that in embryonic somatic cells. The mutation frequency...

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Identifiers

PMID: 11891338
DOI: 10.1073/pnas.062527199
PMCID: PMC122567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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