Enhanced genetic integrity in mouse germ cells.

doi:10.1095/biolreprod.112.103481

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Enhanced genetic integrity in mouse germ cells.

Biology of reproduction - 1 Jan 2013

Murphey Patricia, McLean Derek J, McMahan C Alex, Walter Christi A, McCarrey John R

Abstract excerpt

Genetically based diseases constitute a major human health burden, and de novo germline mutations represent a source of heritable genetic alterations that can cause such disorders in offspring. The availability of transgenic rodent systems with recoverable, mutation reporter genes has been used to assess the occurrence of spontaneous point mutations in germline cells. Previous studies using the lacI mutation...

Topics

Animals
Female
Gene Expression Regulation, Developmental
Genes, Reporter
Germ Cells
Lac Repressors
Liver
Male
Mice
Mice, Transgenic
Mutation
Oocytes
Sertoli Cells
Spermatogonia
Thy-1 Antigens

Source

Open in PubMed Open full text

Identifiers

PMID: 23153565
DOI: 10.1095/biolreprod.112.103481
PMCID: PMC4434944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics