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Article

Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells.

Biochemical and biophysical research communications - 22 Mar 2002

Yamaoka Takashi, Yoshino Kenji, Yamada Taketo, Yano Makiko, Matsui Takefumi, Yamaguchi Takashi, Moritani Maki, Hata Jun-ichi, Noji Sumihare, Itakura Mitsuo

Abstract excerpt

FGF signaling is essential for normal development of pancreatic islets. To examine the effects of overexpressed FGF8 and FGF10 on pancreatic development, we generated FGF8- and FGF10-transgenic mice (Tg mice) under the control of the glucagon promoter. In FGF8-Tg mice, hepatocyte-like cells were observed in the periphery of pancreatic islets, but areas of alpha and beta cells did not decrease, whereas in FGF10-Tg...

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Identifiers

PMID: 11890684
DOI: 10.1006/bbrc.2002.6601

Genes

FGF10
FGF8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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