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Article

Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas.

Nature - 22 May 1997

St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P

Abstract excerpt

The functional unit of the endocrine pancreas is the islet of Langerhans. Islets are nested within the exocrine tissue of the pancreas and are composed of alpha-, beta-, delta- and gamma-cells. beta-Cells produce insulin and form the core of the islet, whereas alpha-, delta- and gamma-cells are arranged at the periphery of the islet and secrete glucagon, somatostatin and a pancreatic polypeptide, respectively....

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Source

Identifiers

PMID: 9163426
DOI: 10.1038/387406a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Related research

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Research trail→

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Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas.PMID 9163426Read ↗

The Developmental Regulator Pax6 Is Essential for Maintenance of Islet Cell Function in the Adult Mouse PancreasSemantic proximity Read ↗

Pax4 in Health and DiabetesSemantic proximity Read ↗

Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription.Semantic proximity Read ↗

The Gene Pax4 Is an Essential Regulator of Pancreatic β-Cell DevelopmentSemantic proximity Read ↗

The gene Pax4 is an essential regulator of pancreatic beta-cell development.Semantic proximity Read ↗

[Transcription Factor PAX4: Role in Differentiation of Insulin- Producing β Cells during Pancreas Development and Association with Diabetes].Semantic proximity Read ↗

Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas.Semantic proximity Read ↗

A focus on the role of Pax4 in mature pancreatic islet β-cell expansion and survival in health and diseaseSemantic proximity Read ↗

Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets.Semantic proximity Read ↗

Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content.Semantic proximity Read ↗

PAX6 maintains β cell identity by repressing genes of alternative islet cell typesSemantic proximity Read ↗

NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferationSemantic proximity Read ↗

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