Article
Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function.
Development (Cambridge, England) - 1 Jul 2000
Gannon M, Ray M K, Van Zee K, Rausa F, Costa R H, Wright C V
Abstract excerpt
We used transgenesis to explore the requirement for downregulation of hepatocyte nuclear factor 6 (HNF6) expression in the assembly, differentiation, and function of pancreatic islets. In vivo, HNF6 expression becomes downregulated in pancreatic endocrine cells at 18. 5 days post coitum (d.p.c.), when definitive islets first begin to organize. We used an islet-specific regulatory element (pdx1(PB)) from...
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