Article
Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas.
The EMBO journal - 15 May 1997
Böttinger E P, Jakubczak J L, Roberts I S, Mumy M, Hemmati P, Bagnall K, Merlino G, Wakefield L M
Abstract excerpt
Using a dominant-negative mutant receptor (DNR) approach in transgenic mice, we have functionally inactivated transforming growth factor-beta (TGF-beta) signaling in select epithelial cells. The dominant-negative mutant type II TGF-beta receptor blocked signaling by all three TGF-beta isoforms in...
Topics
- Animals
- Apoptosis
- Cell Differentiation
- Cell Division
- Fibronectins
- Gene Expression
- Homeostasis
- Immunohistochemistry
- Liver
- Metallothionein
- Mice
- Mice, Transgenic
- Mutation
- Pancreas