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Article

Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia.

Gastroenterology - 1 Apr 2003

Means Anna L, Ray Kevin C, Singh Amar B, Washington M Kay, Whitehead Robert H, Harris Raymond C, Wright Christopher V E, Coffey Robert J, Leach Steven D

Abstract excerpt

BACKGROUND & AIMS: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is expressed in both normal pancreatic islets and in pancreatic cancers, but its role in pancreatic physiology and disease is not known. This report examines the effects of HB-EGF overexpression in mouse pancreas. METHODS: Transgenic mice were established using a tissue-specific promoter to express an HB-EGF complementary DNA...

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Source

Identifiers

PMID: 12671899
DOI: 10.1053/gast.2003.50150

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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