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Transgenic mice overexpressing insulin-like growth factor-II in β cells develop type 2 diabetes

15 Mar 2000

Abstract excerpt

During embryonic development, insulin-like growth factor-II (IGF-II) participates in the regulation of islet growth and differentiation. We generated transgenic mice (C57BL6/SJL) expressing IGF-II in beta cells under control of the rat Insulin I promoter in order to study the role of islet hyperplasia and hyperinsulinemia in the development of type 2 diabetes. In contrast to islets from control mice, islets from...

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PMID: 10727441
DOI: 10.1172/jci5656

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