Article
Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals.
International immunology - 1 Mar 2002
Yasui Teruhito, Muraoka Masaaki, Takaoka-Shichijo Yuko, Ishida Isao, Takegahara Noriko, Uchida Junji, Kumanogoh Atsushi, Suematsu Sachiko, Suzuki Misao, Kikutani Hitoshi
Abstract excerpt
CD40 is essential for efficient humoral immune responses. CD40 has two cytoplasmic domains required for binding of tumor necrosis factor receptor-associated factors (TRAF). The TRAF6-binding site is within the membrane proximal cytoplasmic (Cmp) region, while a PXQXT motif in the membrane distal cytoplasmic (Cmd) region needs to engage TRAF2/3/5. To dissect CD40 signals necessary for B cell differentiation, we...
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