Article
Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation.
Science immunology - 24 Jan 2020
Misawa Takuma, SoRelle Jeffrey A, Choi Jin Huk, Yue Tao, Wang Kuan-Wen, McAlpine William, Wang Jianhui, Liu Aijie, Tabeta Koichi, Turer Emre E, Evers Bret, Nair-Gill Evan, Poddar Subhajit, Su Lijing, Ou Feiya, Yu Liyang, Russell Jamie, Ludwig Sara, Zhan Xiaoming, Hildebrand Sara, Li Xiaohong, Tang Miao, Murray Anne R, Moresco Eva Marie Y, Beutler Bruce
Abstract excerpt
T follicular helper cells (TFH) participate in germinal center (GC) development and are necessary for B cell production of high-affinity, isotype-switched antibodies. In a forward genetic screen, we identified a missense mutation in Prkd2, encoding the serine/threonine kinase protein kinase D2, which caused elevated titers of immunoglobulin E (IgE) in the serum. Subsequent analysis of serum antibodies in mice...
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