Article
Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2013
Hollister Kristin, Kusam Saritha, Wu Hao, Clegg Ninah, Mondal Arpita, Sawant Deepali V, Dent Alexander L
Abstract excerpt
The transcriptional repressor Bcl6 controls development of the follicular Th cell (T(FH)) lineage, but the precise mechanisms by which Bcl6 regulates this process are unclear. A model has been proposed whereby Bcl6 represses the differentiation of T cells into alternative effector lineages, thus favoring T(FH) cell differentiation. Analysis of T cell differentiation using Bcl6-deficient mice has been complicated...
Topics
- Animals
- B-Lymphocyte Subsets
- Cell Differentiation
- Cell Survival
- DNA-Binding Proteins
- Gene Expression
- Gene Knockout Techniques
- Gene Order
- Gene Targeting
- Germinal Center
- Interleukin-10
- Mice
- Mice, Transgenic