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Article

Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms.

Nature immunology - 1 Apr 2013

Huang Chuanxin, Hatzi Katerina, Melnick Ari

Abstract excerpt

The transcription factor Bcl-6 orchestrates germinal center (GC) reactions through its actions in B cells and T cells and regulates inflammatory signaling in macrophages. Here we found that genetic replacement with mutated Bcl6 encoding Bcl-6 that cannot bind corepressors to its BTB domain resulted in disruption of the formation of GCs and affinity maturation of immunoglobulins due to a defect in the...

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Identifiers

PMID: 23455674
DOI: 10.1038/ni.2543
PMCID: PMC3604075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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