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Article

The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.

Cell reports - 11 Sept 2014

Huang Chuanxin, Gonzalez David G, Cote Christine M, Jiang Yanwen, Hatzi Katerina, Teater Matt, Dai Kezhi, Hla Timothy, Haberman Ann M, Melnick Ari

Abstract excerpt

To understand how the Bcl6 transcriptional repressor functions in the immune system, we disrupted its RD2 repression domain in mice. Bcl6RD2(MUT) mice exhibit a complete loss of germinal center (GC) formation but retain normal extrafollicular responses. Bcl6RD2(MUT) antigen-engaged B cells migrate to the interfollicular zone and interact with cognate T helper cells. However, these cells fail to complete early...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25176650
DOI: 10.1016/j.celrep.2014.07.059
PMCID: PMC4163070

Genes

BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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