Article
Mice deficient for CD137 ligand are predisposed to develop germinal center-derived B-cell lymphoma.
Blood - 10 Sept 2009
Middendorp Sabine, Xiao Yanling, Song Ji-Ying, Peperzak Victor, Krijger Peter H L, Jacobs Heinz, Borst Jannie
Abstract excerpt
In the germinal center (GC), B cells proliferate dramatically and diversify their immunoglobulin genes, which increases the risk of malignant transformation. The GC B-cell reaction relies on crosstalk with follicular dendritic cells (FDCs), to which the costimulatory receptor CD137 on FDCs and its ligand on GC B cells potentially contribute. We report that mice deficient for CD137 ligand (CD137L) are predisposed...
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