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Article

Nucleotides of transcription factor binding sites exert interdependent effects on the binding affinities of transcription factors.

Nucleic acids research - 1 Mar 2002

Bulyk Martha L, Johnson Philip L F, Church George M

Abstract excerpt

We can determine the effects of many possible sequence variations in transcription factor binding sites using microarray binding experiments. Analysis of wild-type and mutant Zif268 (Egr1) zinc fingers bound to microarrays containing all possible central 3 bp triplet binding sites indicates that the nucleotides of transcription factor binding sites cannot be treated independently. This indicates that the current...

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Identifiers

PMID: 11861919
DOI: 10.1093/nar/30.5.1255
PMCID: PMC101241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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