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Article

Genome-wide inference of transcription factor-DNA binding specificity in cell regeneration using a combination strategy.

Chemical biology & drug design - 1 Nov 2012

Wang Xiaofeng, Zhang Aiqun, Ren Weizheng, Chen Caiyu, Dong Jiahong

Abstract excerpt

The cell growth, development, and regeneration of tissue and organ are associated with a large number of gene regulation events, which are mediated in part by transcription factors (TFs) binding to cis-regulatory elements involved in the genome. Predicting the binding affinity and inferring the binding specificity of TF-DNA interactions at the genomic level would be fundamentally helpful for our understanding of...

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PMID: 22863142
DOI: 10.1111/cbdd.12013

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