Article
Experimental analysis and computer prediction of CTF/NFI transcription factor DNA binding sites.
Journal of molecular biology - 7 Apr 2000
Roulet E, Bucher P, Schneider R, Wingender E, Dusserre Y, Werner T, Mermod N
Abstract excerpt
Accurate prediction of transcription factor binding sites is needed to unravel the function and regulation of genes discovered in genome sequencing projects. To evaluate current computer prediction tools, we have begun a systematic study of the sequence-specific DNA-binding of a transcription factor belonging to the CTF/NFI family. Using a systematic collection of rationally designed oligonucleotides combined...
Topics
- Adenoviruses, Human
- Algorithms
- Base Sequence
- Binding Sites
- CCAAT-Enhancer-Binding Proteins
- Cell Line
- Computer Simulation
- Consensus Sequence
- DNA
- DNA-Binding Proteins
- Dimerization
- Humans
- Mutation
- NFI Transcription Factors