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Article

DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins.

Cell - 22 Mar 2018

Patel Anamika, Yang Peng, Tinkham Matthew, Pradhan Mihika, Sun Ming-An, Wang Yixuan, Hoang Don, Wolf Gernot, Horton John R, Zhang Xing, Macfarlan Todd, Cheng Xiaodong

Abstract excerpt

Tandem zinc finger (ZF) proteins are the largest and most rapidly diverging family of DNA-binding transcription regulators in mammals. ZFP568 represses a transcript of placental-specific insulin like growth factor 2 (Igf2-P0) in mice. ZFP568 binds a 24-base pair sequence-specific element upstream of Igf2-P0 via the eleven-ZF array. Both DNA and protein conformations deviate from the conventional one finger-three...

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Identifiers

PMID: 29551271
DOI: 10.1016/j.cell.2018.02.058
PMCID: PMC5877318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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