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Article

Extensive characterization of NF-κB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits.

Genome biology - 29 Jul 2011

Wong Daniel, Teixeira Ana, Oikonomopoulos Spyros, Humburg Peter, Lone Imtiaz Nisar, Saliba David, Siggers Trevor, Bulyk Martha, Angelov Dimitar, Dimitrov Stefan, Udalova Irina A, Ragoussis Jiannis

Abstract excerpt

BACKGROUND: Genetic studies have provided ample evidence of the influence of non-coding DNA polymorphisms on trait variance, particularly those occurring within transcription factor binding sites. Protein binding microarrays and other platforms that can map these sites with great precision have enhanced our understanding of how a single nucleotide polymorphism can alter binding potential within an in vitro...

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Identifiers

PMID: 21801342
DOI: 10.1186/gb-2011-12-7-r70
PMCID: PMC3218832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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