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Article

Role of promoter DNA sequence variations on the binding of EGR1 transcription factor.

Archives of biochemistry and biophysics - 1 May 2014

Mikles David C, Schuchardt Brett J, Bhat Vikas, McDonald Caleb B, Farooq Amjad

Abstract excerpt

In response to a wide variety of stimuli such as growth factors and hormones, EGR1 transcription factor is rapidly induced and immediately exerts downstream effects central to the maintenance of cellular homeostasis. Herein, our biophysical analysis reveals that DNA sequence variations within the target gene promoters tightly modulate the energetics of binding of EGR1 and that nucleotide substitutions at certain...

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Share to Protein Binding
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Models, Molecular

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 24657079
DOI: 10.1016/j.abb.2014.03.005
PMCID: PMC4006273

Genes

EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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