Article
Dinucleotide repeat polymorphism in interferon-gamma gene is not associated with sporadic Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2004
Oda Masaya, Maruyama Hirofumi, Izumi Yuishin, Morino Hiroyuki, Torii Tsuyoshi, Nakamura Shigenobu, Kawakami Hideshi
Abstract excerpt
Various factors have been suggested to participate in Alzheimer's disease (AD) pathology, and some inflammatory cytokines may play an important role in the development of AD. Interferon-gamma (IFNG), an important pro-inflammatory cytokine, is encoded by a single gene mapped to chromosome 12, one of the candidate locus of AD. The first intron in the IFNG gene represents a CA repeat polymorphism that is possible to...
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