Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Failure to replicate a protective effect of allele 2 of NACP/alpha-synuclein polymorphism in Alzheimer's disease: an association study.

Annals of neurology - 1 Aug 1998

Hellman N E, Grant E A, Goate A M

Abstract excerpt

Recently, a dinucleotide repeat polymorphism was identified in the promoter of the nonamyloid component of plaques (NACP) gene, and it was shown that the NACP allele 2 was significantly associated with healthy elderly control individuals with at least one apolipoprotein E epsilon4 allele, suggesting a protective role for this allele in Alzheimer's disease. We genotyped the same NACP polymorphism in a comparable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Base Sequence

Share to Gene Frequency

Share to Genotype

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 9708555
DOI: 10.1002/ana.410440223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Failure to replicate a protective effect of allele 2 of NACP/alpha-synuclein polymorphism in Alzheimer's disease: an association study.PMID 9708555Read ↗

Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism.Semantic proximity Read ↗

Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population.Semantic proximity Read ↗

Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases.Semantic proximity Read ↗

Dinucleotide repeat polymorphisms in the neprilysin gene are not associated with sporadic Alzheimer's disease.Semantic proximity Read ↗

Characterization of the human α-synuclein gene: Genomic structure, transcription start site, promoter region and polymorphismsSemantic proximity Read ↗

Polymorphism of NACP-Rep1 in Parkinson's disease: an etiologic link with essential tremor?Semantic proximity Read ↗

Genetic deficiency of plasma lipoprotein-associated phospholipase A2 (PLA2G7 V297F null mutation) and risk of Alzheimer's disease in Japan.Semantic proximity Read ↗

The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier association.Semantic proximity Read ↗

Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease.Semantic proximity Read ↗

Association between neprilysin polymorphisms and sporadic Alzheimer's disease.Semantic proximity Read ↗

Tau polymorphisms are not associated with Alzheimer's disease.Semantic proximity Read ↗

Alpha synuclein promoter and risk of Parkinson's disease: microsatellite and allelic size variability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.