Article
Failure to replicate a protective effect of allele 2 of NACP/alpha-synuclein polymorphism in Alzheimer's disease: an association study.
Annals of neurology - 1 Aug 1998
Hellman N E, Grant E A, Goate A M
Abstract excerpt
Recently, a dinucleotide repeat polymorphism was identified in the promoter of the nonamyloid component of plaques (NACP) gene, and it was shown that the NACP allele 2 was significantly associated with healthy elderly control individuals with at least one apolipoprotein E epsilon4 allele, suggest...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid
- Apolipoproteins E
- Base Sequence
- Chi-Square Distribution
- Dinucleotide Repeats
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Middle Aged
- Nerve Tissue Proteins
- Odds Ratio
- Phosphoproteins
- Polymorphism, Genetic