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Article

Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate.

Antimicrobial agents and chemotherapy - 1 Jul 1998

Haimeur A, Ouellette M

Abstract excerpt

Leishmania tarentolae promastigotes were selected step by step for resistance to sodium stibogluconate (Pentostam). Mutants resistant to antimony-containing drugs and cross-resistant to arsenite were therefore obtained. Amplification of one common locus was observed in several independent sodium...

Topics

Amino Acid Sequence
Animals
Antimony Sodium Gluconate
Antiprotozoal Agents
Base Sequence
DNA, Protozoan
Drug Resistance
Gene Amplification
Leishmania
Molecular Sequence Data
Mutation
Protozoan Proteins

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Identifiers

PMID: 9661005
DOI: 10.1128/AAC.42.7.1689
PMCID: PMC105667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9661005-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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