Article
High level arsenite resistance in Leishmania tarentolae is mediated by an active extrusion system.
Molecular and biochemical parasitology - 1 Sept 1994
Dey S, Papadopoulou B, Haimeur A, Roy G, Grondin K, Dou D, Rosen B P, Ouellette M
Abstract excerpt
Leishmania tarentolae cells selected for resistance to the oxyanions pentavalent or trivalent antimonials or to trivalent arsenicals exhibited cross-resistance to the other oxyanions. The basis for resistance in these mutants was studied by transport experiments using radioactive arsenite. All mu...
Topics
- Animals
- Antimony
- Arsenites
- Biological Transport, Active
- Drug Resistance
- Drug Synergism
- Leishmania
- Mutation
- Verapamil