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Article

High level arsenite resistance in Leishmania tarentolae is mediated by an active extrusion system.

Molecular and biochemical parasitology - 1 Sept 1994

Dey S, Papadopoulou B, Haimeur A, Roy G, Grondin K, Dou D, Rosen B P, Ouellette M

Abstract excerpt

Leishmania tarentolae cells selected for resistance to the oxyanions pentavalent or trivalent antimonials or to trivalent arsenicals exhibited cross-resistance to the other oxyanions. The basis for resistance in these mutants was studied by transport experiments using radioactive arsenite. All mutants exhibiting high level resistance to arsenite showed a marked decrease in the steady-state accumulation of...

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PMID: 7838183
DOI: 10.1016/0166-6851(94)90095-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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