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Article

Gene disruption of the P-glycoprotein related gene pgpa of Leishmania tarentolae.

Biochemical and biophysical research communications - 25 Jul 1996

Papadopoulou B, Roy G, Dey S, Rosen B P, Olivier M, Ouellette M

Abstract excerpt

Transfection of pgpA into Leishmania confers resistance to arsenite and antimonials. By gene targeting mediated by homologous recombination the two alleles of the pgpA gene of a L. tarentolae wild-type cell were disrupted sequentially with the neomycin and hygromycin phosphotransferase genes. Thi...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Anions
Antimony
Arsenites
Cell Line
Chromosome Mapping
Drug Resistance, Multiple
Ion Transport
Kanamycin Kinase
Leishmania
Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Phenotype

Phosphotransferases (Alcohol Group Acceptor)

Source

Identifiers

PMID: 8713121
DOI: 10.1006/bbrc.1996.1098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8713121-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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