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Article

Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum.

Nucleic acids research - 1 Apr 2009

Leprohon Philippe, Légaré Danielle, Raymond Frédéric, Madore Eric, Hardiman Gary, Corbeil Jacques, Ouellette Marc

Abstract excerpt

Antimonials remain the first line drug against the protozoan parasite Leishmania but their efficacy is threatened by resistance. We carried out a RNA expression profiling analysis comparing an antimony-sensitive and -resistant (Sb2000.1) strain of Leishmania infantum using whole-genome 70-mer oligonucleotide microarrays. Several genes were differentially expressed between the two strains, several of which were...

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Identifiers

PMID: 19129236
DOI: 10.1093/nar/gkn1069
PMCID: PMC2655676

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Source receipt: pubmed, retrieved 7 Sept 2026.

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