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Article

The retinoblastoma protein alters the phosphorylation state of polyomavirus large T antigen in murine cell extracts and inhibits polyomavirus origin DNA replication.

Journal of virology - 1 Apr 1999

Reynisdóttir I, Bhattacharyya S, Zhang D, Prives C

Abstract excerpt

The retinoblastoma tumor suppressor protein (pRb) can associate with the transforming proteins of several DNA tumor viruses, including the large T antigen encoded by polyomavirus (Py T Ag). Although pRb function is critical for regulating progression from G1 to S phase, a role for pRb in S phase has not been demonstrated or excluded. To identify a potential effect of pRb on DNA replication, pRb protein was added...

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Source

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Identifiers

PMID: 10074150
DOI: 10.1128/JVI.73.4.3004-3013.1999
PMCID: PMC104060

Genes

CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The retinoblastoma protein alters the phosphorylation state of polyomavirus large T antigen in murine cell extracts and inhibits polyomavirus origin DNA replication.PMID 10074150Read ↗

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment.Semantic proximity Read ↗

Host range and cell cycle activation properties of polyomavirus large T-antigen mutants defective in pRB binding.Semantic proximity Read ↗

pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.Semantic proximity Read ↗

Post-translational modifications on the retinoblastoma proteinSemantic proximity Read ↗

PRMT4-mediated arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation.Semantic proximity Read ↗

The B-domain lysine patch of pRB is required for binding to large T antigen and release of E2F by phosphorylation.Semantic proximity Read ↗

Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression.Semantic proximity Read ↗

Interaction of retinoblastoma protein family members with large T-antigen of primate polyomavirusesSemantic proximity Read ↗

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.Semantic proximity Read ↗

Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteinsSemantic proximity Read ↗

Structure-function analysis of the retinoblastoma tumor suppressor protein – is the whole a sum of its parts?Semantic proximity Read ↗

Role of the Retinoblastoma Protein in Differentiation and SenescenceSemantic proximity Read ↗

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