Article
NF-kappa B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutants.
The Journal of biological chemistry - 25 Apr 2003
Takebayashi Tetsuro, Higashi Hideaki, Sudo Hideki, Ozawa Heita, Suzuki Etsu, Shirado Osamu, Katoh Hiroyuki, Hatakeyama Masanori
Abstract excerpt
The retinoblastoma protein (pRB) and its homologues, p107 and p130, prevent cell cycle progression from G(0)/G(1) to S phase by forming complexes with E2F transcription factors. Upon phosphorylation by G(1) cyclin-cyclin-dependent kinase (Cdk) complexes such as cyclin D1-Cdk4/6 and cyclin E-Cdk2, they lose the ability to bind E2F, and cells are thereby allowed to progress into S phase. Functional loss of one or...
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