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Article

Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation.

Molecular and cellular biology - 1 Oct 1995

Zalvide J, DeCaprio J A

Abstract excerpt

Simian virus 40 large T-antigen (TAg) transformation is thought to be mediated, at least in part, by binding to and modulating the function of certain cellular proteins, including the retinoblastoma tumor suppressor gene product, pRb. TAg can disrupt the inhibitory complexes formed by pRb with the oncogenic transcription factor E2F, and this mechanism has been suggested to be important for TAg-mediated...

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Identifiers

PMID: 7565733
DOI: 10.1128/MCB.15.10.5800
PMCID: PMC230832

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Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation.PMID 7565733Read ↗

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