Article
Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation.
Molecular and cellular biology - 1 Oct 1995
Zalvide J, DeCaprio J A
Abstract excerpt
Simian virus 40 large T-antigen (TAg) transformation is thought to be mediated, at least in part, by binding to and modulating the function of certain cellular proteins, including the retinoblastoma tumor suppressor gene product, pRb. TAg can disrupt the inhibitory complexes formed by pRb with th...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Antigens, Polyomavirus Transforming
- Base Sequence
- Carrier Proteins
- Cell Cycle Proteins
- Cell Transformation, Viral
- DNA-Binding Proteins
- E2F Transcription Factors
- Fibroblasts
- Genotype
- Mice
- Mice, Knockout
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Phosphoproteins