Article
Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation.
Molecular and cellular biology - 1 Jan 2008
Magenta Alessandra, Fasanaro Pasquale, Romani Sveva, Di Stefano Valeria, Capogrossi Maurizio C, Martelli Fabio
Abstract excerpt
The retinoblastoma tumor suppressor protein (pRb) regulates cell proliferation and differentiation via phosphorylation-sensitive interactions with specific targets. While the role of cyclin/cyclin-dependent kinase complexes in the modulation of pRb phosphorylation has been extensively studied, relatively little is known about the molecular mechanisms regulating phosphate removal by phosphatases. Protein...
Topics
- Calcium
- Cells, Cultured
- Dimerization
- Humans
- Hydrogen Peroxide
- Mutation
- Phosphorylation
- Protein Binding
- Protein Phosphatase 2
- Protein Subunits
- Retinoblastoma Protein