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Interaction of the Betapapillomavirus E2 Tethering Protein with Mitotic Chromosomes

22 Oct 2009

Abstract excerpt

During persistent papillomavirus infection, the viral E2 protein tethers the viral genome to the host cell chromosomes, ensuring maintenance and segregation of the viral genome during cell division. However, E2 proteins from different papillomaviruses interact with distinct chromosomal regions and targets. The tethering mechanism has been best characterized for bovine papillomavirus type 1 (BPV1), where the E2...

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PMID: 19846509
DOI: 10.1128/jvi.01908-09

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